What are the risk factors for Gout?
Gout is caused by too much uric acid in the blood (hyperuricemia). The following risk factors can either cause hyperuricemia or make joints more susceptible to the formation of uric acid crystals:
• Being male
• Family history of gout
• Moderate, regular, or heavy consumption of alcohol, especially beer
• A diet rich in meat and seafood, which can be high in purines
• Use of medicines that remove salt and water from the body (diuretics)
• Regular use of aspirin (more than 1 or 2 aspirin a day)
• Frequent episodes of dehydration
• Acute illness or infection
• Lead exposure (may occur through work, diet, or hobbies)
• Very low-calorie diets
• Injury to a joint
What conditions are associated with Gout?
Certain other conditions and diseases appear more often in people who have gout than in people who don't, though studies have not shown a clear relationship. It is thought that gout shares risk factors (such as obesity, hypertension, and high levels of triglycerides) with certain diseases, including:
• Kidney (renal) disease.
• Hardening of the arteries (atherosclerosis).
• Heart disease.
Which Medicines and Supplements are bad for Gout?
Some medicines that are prescribed for other conditions can inhibit the natural elimination of uric acid. This includes diuretics or water pills, and niacin. Low dose aspirin may raise the level of uric acid, although can be very important for the prevention of a stroke or a heart attack.
High levels of Vitamin B3 and Vitamin A can increase uric acid levels and contribute to development of Gout.
A recent study looked at 415 individuals between the ages of 21 and 82 years who had participated in a lifestyle modification project. It found that among the main factors associated with high levels of uric acid were obesity and muscle hypotrophy (which can occur from body building, etc).
Lead toxicity is known to lead to gouty arthritis, or gout. A recent observational study was carried out to investigate if the acceptable levels of lead in blood among adults could also lead to gout. Data of 6153 participants of the Health and Nutrition Examination Survey for 2005 through 2008 were examined. The findings concluded that the blood lead levels currently considered normal are associated with increased prevalence of gout and hyperuricemia.
A Chinese study sought to find associations with purine rich food and protein intake, and hyperuricemia. The diet of 3978 Chinese men were assessed, along with other factors such as life style, and it was found that there was an association between seafood consumption and hyperuricemia and an inverse association between consumption of soy food and hyperuricemia among middle-aged, Chinese men
Use of diuretics has been associated with an increased risk of gout. Patient QI found a study carried out in October 2013, that analysed data from the General Practice Research Database UK found that use of loop, thiazide, and thiazide-like diuretics, but not use of potassium-sparing agents, was associated with an increased risk of incident gout. Another previous study also concluded the strong association between the use of loop, thiazide, and thiazide-like diuretics with an increased risk of incident gout, but also noted the association with recent use of other diuretics and increased risk of gout.
Alcohol has long been associated with the risk of gout, and a recent American internet based study sought to assess if it is dependent on quantity and type of alcohol. The study included 724 patients with gout, 78% being men with a mean age of 54. It concluded that the risk of gout was increased by episodic alcohol consumption, regardless of the type of alcoholic beverage, and even by moderate consumption. It recommends that persons with gout should limit alcohol intake of all types to reduce the risk of recurrent gout attacks.
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