Vitamin C Ovarian Cancer Treatment
High dose Vitamin C was one of the early non conventional treatments for cancer. The treatment had a good safety record and benefits were claimed by many patients and some of the medical profession, however two clinical trials of high dose oral Vitamin C showed no clear benefit and it's use was then abandoned. A new study published this month has shown that unlike oral Vit C, parenteral (injected into the muscle or the veins) high dose Vitamin C gets it into the interstitial fluid around tumour cells where it carries out a local pro-oxidant effect, mediating hydrogen peroxide (H2O2) formation, which kills cancer cells. The study investigated a combination of parenteral Vitamin C with conventional chemotherapy in an animal model of ovarian cancer. Results showed a reduction in chemotherapy-associated toxicity and improved death in ovarian cancer cells. Future clinical trials of intravenous Vitamin C in combination with chemotherapy are suggested.
Ma et al. High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Scie Transl Med . Feb 2014.
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